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KMID : 0352419920110030369
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Keimyung Medical Journal
1992 Volume.11 No. 3 p.369 ~ p.380
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α-D-Mannosidase, β-D-Mannosidase, α-D-Glucosidase and β-D-Glucosidase Activities in Regenerating Rat Liver
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Abstract
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A study was made on the changes of α-D-mannosidase, β-D-mannosidase, α-D-glucosidase and β-D-glucosidase activities in regenerating rat liver.
The cytosolic, lysosomal, Golgi and microsomal α-D-mannosidase, lysosomal β-D-mannosidase, lysosomal α-D-glucosidase, cytosolic broad specificity β-D-glucosidase and lysosomal acid α-D-glucosidase activities were determined in the
regenerating
liver after 70%(median and left lateral lobers) partial hepatectomy in rate over a period of ten days. The activities of cytolic, lysosomal and Golgi α-D-mannosidase, lysosomal β-D-mannosidase and lysosomal α-D-glucosidase in the serum were
measured
together with the above determination of hepatic glycosidase.
The activities of cytotoslic α-D-mannosidase of the serum and regenerating liver decreased slightly between the second and the third days after partial hepatectomy.
The activity of lysosomal α-D-mannosidase in the regenerating liver decreased significantly between the first and the third days after partial heaptectomy. The lysosomal α-D-mannosidase in the serum decreased substantially on the second and the
third
days after operation.
The activity of Golig α-D-mannosidase in the regenerating liver decreased significantly on the third day after partial hepatectomy. However, no significant change in the serum Golgi α-D-mannosidase activity was noted throughout the experiments.
The microsomal α-D-mannosidase activity in the regenerating liver had a slight diminution between the second and the sixth days after partial hepatectomy.
The lysosomal β-D-mannosidase activity in the regenerating liver significantly decreased on the second day after partial hepatectomy.l that of serum lysosomal β-D-mannosidaseshowed a slight decrease form the second day after operation.
The lysosomal α-D-glucosidase activity in the regenerating liver showed a slight decrease between the first and the third days after partial hepatectomy, while the serum lysosomal α-D-gluosidase activity did not change.
The cytosolic broad-specificity β-D-glucosidase activity in the regenerating liver slightly decerased between the second and the third days after partial hepatectomy. The lysosomal acid β-D-glucosidase activity in the regenerating liver
considerably
decreased between the first and the third days after operation.
Summarizing the results, α-D-mannosidase, β-D-mannosidase, α-D-glucosidase and β-D-glucosidase in the regeneragint lvier thought to be the enzymes decreasing their activities in the regenerating stage.
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KEYWORD
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